Pharmacogenomic analysis of low-density lipoprotein receptor 3’ untranslated region genetic variants influencing rosuvastatin efficacy in Chinese dyslipidemia patients
These findings highlight the role of LDLR 3'UTR as a critical pharmacogenomic locus. Our results advance understanding of genetic predictors for personalized statin therapy.
Authors
- Songnian Hu (ORCID: https://orcid.org/0000-0003-3966-3111)
- Zhuo Wang (ORCID: https://orcid.org/0000-0001-6054-8156)
- Jingli Qin
- Guoqiang Zhang
- Ningling Sun (ORCID: https://orcid.org/0000-0003-0378-2813)
- Keke Wang (ORCID: https://orcid.org/0000-0001-8617-1895)
- Yanwei Zhang (ORCID: https://orcid.org/0000-0002-0230-6279)
- Hong Yuan (ORCID: https://orcid.org/0000-0002-6214-6879)
- Yan Tian
- Luyan Wang (ORCID: https://orcid.org/0000-0003-4605-2490)
- Yihua Zhu (ORCID: https://orcid.org/0009-0006-8054-8261)
- Yayu Ma (ORCID: https://orcid.org/0009-0003-2658-6142)
Institutions
- Nanjing Agricultural University (CN)
- Central South University (CN)
- Chinese Academy of Sciences (CN)
- Peking University (CN)
- Czech Academy of Sciences, Institute of Microbiology (CZ)
- Peking University People's Hospital (CN)
- Tengzhou Central People's Hospital (CN)
- OriginWater (China) (CN)
- Third Xiangya Hospital (CN)
- Clinical Research Management (US)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Pharmacogenetics and Genomics
- Published
- 2025-09-03
- DOI
- https://doi.org/10.1097/fpc.0000000000000575
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00