Regulation of PD-L1 Expression by SAHA-Mediated Histone Deacetylase Inhibition in Lung Cancer Cells

Our results suggest that SAHA can be used along with immune checkpoint inhibitors to potentiate the therapeutic outcomes in patients with excessive immunosuppression due to PD-L1 expression.

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Publication Details

Journal
Cancers
Published
2025-09-05
DOI
https://doi.org/10.3390/cancers17172919
Primary Topic
Histone Deacetylase Inhibitors Research
Type
article
Field-Weighted Citation Impact
0.00

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article

Regulation of PD-L1 Expression by SAHA-Mediated Histone Deacetylase Inhibition in Lung Cancer Cells

Umamaheswari Natarajan, Appu Rathinavelu
Cancers
Histone Deacetylase Inhibitors Research
article

Regulation of PD-L1 Expression by SAHA-Mediated Histone Deacetylase Inhibition in Lung Cancer Cells

Umamaheswari Natarajan, Appu Rathinavelu
article en

Abstract

Our results suggest that SAHA can be used along with immune checkpoint inhibitors to potentiate the therapeutic outcomes in patients with excessive immunosuppression due to PD-L1 expression.

CancersVol. 17(17)
Nova Southeastern University (US)
Nova Southeastern University
Openalex Percentile: Top 79%
Histone Deacetylase Inhibitors Research
DOIOpen Access PDFOpenAlex
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Regulation of PD-L1 Expression by SAHA-Mediated Histone Deacetylase Inhibition in Lung Cancer Cells — Umamaheswari Natarajan, Appu Rathinavelu · Cancers (2025) | TGRS Research Map | TGRS