HIV-1 genetic diversity and pretreatment drug resistance survey prior to dolutegravir introduction in Senegal
Through a quasi-national survey, an intermediate level of NNRTI resistance was observed, with regional disparities in Senegal. These findings highlight the limitations of NNRTI-based first-line regimens in Senegal and support the transition to other antiretroviral therapy regimens, such as dolutegravir-based therapy in newly infected individuals as well as in treated patients.
Authors
- Halimatou Diop‐Ndiaye (ORCID: https://orcid.org/0000-0001-5885-5448)
- Edmond Tchiakpé (ORCID: https://orcid.org/0000-0003-3594-2105)
- Nafissatou Lèye
- Abou Abdallah Malick Diouara (ORCID: https://orcid.org/0000-0003-3658-6245)
- Coumba Touré‐Kâne (ORCID: https://orcid.org/0000-0003-0496-8230)
- Nicole Vidal (ORCID: https://orcid.org/0000-0001-7022-2643)
- Fatou Niasse
- Mengue Fall
- Fabien Roch Niama
- M. Thiam
- Safiatou Thiam
- Bambo Diakhaby
Institutions
- Agropolis International (FR)
- Comité National de Lutte contre le SIDA (CM)
- Institute of Health Research, Epidemiological Surveillance and Training (SN)
- Université d'Abomey-Calavi (BJ)
- Marien Ngouabi University (CG)
- Cheikh Anta Diop University (SN)
Publication Details
- Journal
- IJID Regions
- Published
- 2025-09-05
- DOI
- https://doi.org/10.1016/j.ijregi.2025.100741
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00