Clinical and biological factors associated with response to immune checkpoint inhibitors in advanced sarcomas: IMPRESARC, a French retrospective multicenter cohort study
Despite a short median PFS, certain histological subtypes, including ASPS, chordomas, SMARCA4-deficient tumors, gastro-intestinal stromal tumor, and NF1 mutations, showed strong activity signals, indicating long-term responses in some patients.
Authors
- Benjamin Verret
- Hélène Vanacker
- Françoise Ducimetière (ORCID: https://orcid.org/0000-0003-2889-685X)
- Sarah Watson (ORCID: https://orcid.org/0000-0003-4534-8783)
- Jean‐Yves Blay (ORCID: https://orcid.org/0000-0001-7190-120X)
- Alexandra Meurgey (ORCID: https://orcid.org/0009-0003-8568-8640)
- Armelle Dufresne (ORCID: https://orcid.org/0000-0002-6637-3526)
- Waïsse Waïssi (ORCID: https://orcid.org/0000-0001-9156-2882)
- Nicolas Penel (ORCID: https://orcid.org/0000-0001-5243-1548)
- Thibaud Valentin
- Romain Varnier (ORCID: https://orcid.org/0000-0003-3357-6914)
- Mehdi Brahmi (ORCID: https://orcid.org/0000-0001-9904-166X)
- Emmanuelle Bompas (ORCID: https://orcid.org/0000-0003-4414-7760)
- Mina Fazel (ORCID: https://orcid.org/0000-0003-3873-6390)
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Inserm (FR)
- Institut Gustave Roussy (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Lille’s Cardiology Hospital (FR)
- Institut universitaire du cancer de Toulouse Oncopole (FR)
- Centre Léon Bérard (FR)
- Institut de Cancérologie de l'Ouest (FR)
- The Lymphoma Academic Research Organisation (FR)
- Centre Oscar Lambret (FR)
- Institut Curie (FR)
Publication Details
- Journal
- Cancer
- Published
- 2025-09-05
- DOI
- https://doi.org/10.1002/cncr.70052
- Citations
- 1
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52