Assessing sample adequacy and clinical performance of self-collected and clinician-collected HPV specimens using internal control Ct values
Both clinician- and self-collected samples showed adequate cellularity, with potentially false negative HPV results from low cellular content appearing rare. Observed patterns suggest Ct <26 as optimal and Ct <28 as a minimum for program-level quality assurance with the BD Onclarity™ HPV Assay.
Authors
- Sara Nordqvist Kleppe (ORCID: https://orcid.org/0000-0002-8892-7497)
- Laila Sara Arroyo Mühr (ORCID: https://orcid.org/0000-0003-2498-5206)
- Clementina Cocuzza (ORCID: https://orcid.org/0000-0001-6166-1134)
- Emel Yilmaz (ORCID: https://orcid.org/0000-0002-2368-7402)
- Camilla Lagheden
- Marianna Martinelli (ORCID: https://orcid.org/0000-0003-2273-6986)
- Sadaf Sakina Hassan (ORCID: https://orcid.org/0009-0000-1794-5199)
Institutions
- Karolinska Institutet (SE)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Journal of Clinical Virology
- Published
- 2025-09-05
- DOI
- https://doi.org/10.1016/j.jcv.2025.105869
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bill and Melinda Gates Foundation