A prospective case–control study: Analysis of the analgesic effect of acetaminophen–mannitol injection after endoscopic lumbar discectomy

ObjectiveTo investigate the analgesic effects of acetaminophen-mannitol injections after endoscopic lumbar discectomy.MethodsThis is a prospective case-control study involving 60 patients who were randomly selected from those who underwent endoscopic lumbar discectomy for lumbar disc herniation or lumbar spinal stenosis at Sanshui District People's Hospital of Foshan between April and September 2024. Two groups were formed by randomly assigning patients, with each group containing 30 individuals. The observation group underwent treatment with acetaminophen-mannitol for pain relief, whereas the control group was administered oral etoricoxib and intravenous mannitol. A comparison was made between the analgesic effects of the two groups.ResultsCompared with the control group, the observation group showed significantly lower visual analog scale scores on the first, third, and seventh days after operation (<i>P</i> < 0.05). The observation group had a similar time to start walking and length of hospital stay as the control group. The total incidence rate of adverse reactions was zero.ConclusionAcetaminophen-mannitol injection has a good analgesic effect after endoscopic lumbar discectomy, which is beneficial for accelerating the postoperative recovery of patients.