<scp>TRIM25</scp>‐Mediated Ubiquitination and Degradation of <scp>SOX8</scp> Promotes Ligament Fibroblast Osteogenic Differentiation and Regulates <scp>OPLL</scp> Progression by Inhibiting <scp>OSR2</scp> Transcription
SOX8 serves as a critical negative regulator of osteogenic differentiation in ligament fibroblasts. TRIM25 promotes ectopic ossification in OPLL by enhancing SOX8 ubiquitination and degradation, while SOX8 inhibits osteogenic differentiation through transcriptional activation of OSR2. These findings highlight the TRIM25/SOX8/OSR2 axis as a key regulator in OPLL ectopic ossification, suggesting it to be a potential target for non-surgical treatment.
Authors
- Ziheng Wei (ORCID: https://orcid.org/0000-0003-2423-9799)
- Zhenqiang Wang
- Yifan Tang (ORCID: https://orcid.org/0009-0005-5239-3832)
- Xiongsheng Chen (ORCID: https://orcid.org/0000-0001-9895-1784)
- Quanwei Zhou (ORCID: https://orcid.org/0000-0003-3939-4118)
- Changjiang Gu (ORCID: https://orcid.org/0000-0001-6887-1978)
- M. �ift�io lu
- Shengyuan Zhou
Institutions
- Fujian Medical University (CN)
- Second Military Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Fourth People's Hospital of Sichuan Province (CN)
- Shanghai Ninth People's Hospital (CN)
- Shanghai Changzheng Hospital (CN)
- Shanghai First People's Hospital (CN)
- Shanghai Sunshine Rehabilitation Center (CN)
Publication Details
- Journal
- JOR Spine
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/jsp2.70112
- Primary Topic
- Cervical and Thoracic Myelopathy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China