Analysis of the mRNA modification machinery alterations in breast cancer through the SCAN-B cohort
Epitranscriptomic modifications regulate gene expression and have been implicated in cancer, including breast cancer. Using the SCAN-B cohort, we analyzed 49 messenger RNA modification regulators (mRMPs) across breast cancer subtypes. In the basal subtype, we found significant overexpression of m<sup>6</sup>A readers (IGF2BP1-3), m<sup>5</sup>C regulators (NSUN5, ALYREF, YBX1, YBX2), pseudouridine [PUS1, MARS (or MetRS), RPUSD2], and RNA editing enzymes [APOBEC3A (A3A), A3G, ADAR1], all linked to poor survival. Conversely, the m<sup>6</sup>A writer METTL14 was downregulated. Our findings highlight key mRMPs as potential biomarkers and therapeutic targets, underscoring the role of RNA modifications in breast cancer progression.
Authors
- Kanchan Kumari (ORCID: https://orcid.org/0000-0001-7546-4174)
- Margalida Esteva-Socias (ORCID: https://orcid.org/0000-0002-8047-9298)
- Erik Dassi (ORCID: https://orcid.org/0000-0003-4487-0449)
- Francesca Aguiló (ORCID: https://orcid.org/0000-0002-2374-2045)
- Carlos Peula
Institutions
- University of Trento (IT)
- Umeå University (SE)
Publication Details
- Journal
- NAR Cancer
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1093/narcan/zcaf027
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Kempe Foundation
- Cancerfonden
- Västerbotten Läns Landsting
- Knut och Alice Wallenbergs Stiftelse
- Vetenskapsrådet
- Umeå Universitet