Moderating effects of plasma glial fibrillary acidic protein along the Alzheimer's disease continuum
AD biomarkers were measured in two demographically and clinically distinct cohorts. Plasma GFAP moderated Aβ-PET to p-tau associations in both UCSF and 1FLADRC. Cohort-dependent, GFAP moderated p-tau to neurodegeneration and cognition associations. All moderations revealed strengthened disease associations with higher plasma GFAP. Plasma GFAP may help identify individuals at greatest risk of AD-related decline.
Authors
- Lawren VandeVrede (ORCID: https://orcid.org/0000-0002-8304-6711)
- Mark Sanderson‐Cimino (ORCID: https://orcid.org/0000-0002-5872-3186)
- Brandon Chan (ORCID: https://orcid.org/0000-0002-5817-6450)
- Julio C. Rojas (ORCID: https://orcid.org/0000-0002-1308-646X)
- Franchesca Arias (ORCID: https://orcid.org/0000-0002-5448-6849)
- Warren Barker (ORCID: https://orcid.org/0000-0003-2171-7142)
- Breton M. Asken
- Adam M. Staffaroni (ORCID: https://orcid.org/0000-0002-3903-9805)
- Renaud La Joie (ORCID: https://orcid.org/0000-0003-2581-8100)
- David E. Vaillancourt (ORCID: https://orcid.org/0000-0002-5663-6476)
- Joel H. Kramer (ORCID: https://orcid.org/0000-0002-2917-8297)
- Rosie E. Curiel (ORCID: https://orcid.org/0000-0001-6505-7030)
- Shannon Y. Lee (ORCID: https://orcid.org/0000-0001-6820-1237)
- Melissa J. Armstrong (ORCID: https://orcid.org/0000-0002-2163-1907)
- Emily F. Matusz (ORCID: https://orcid.org/0000-0002-8255-0641)
- Mónica Rosselli (ORCID: https://orcid.org/0000-0003-2656-9505)
- Michael Marsiske (ORCID: https://orcid.org/0000-0001-5973-2116)
- Wei‐en Wang (ORCID: https://orcid.org/0000-0001-8555-9062)
- Valentina E. Diaz
- Gil Dan Rabinovici (ORCID: https://orcid.org/0000-0002-3626-4265)
- Shellie‐Anne Levy (ORCID: https://orcid.org/0000-0001-5939-2887)
- Sruti Rayaprolu (ORCID: https://orcid.org/0000-0002-5212-3745)
- Jesse C. DeSimone (ORCID: https://orcid.org/0000-0002-3823-8765)
- Glenn E. Smith (ORCID: https://orcid.org/0000-0003-1506-9484)
- David Loewenstein (ORCID: https://orcid.org/0000-0001-6788-2798)
- Brenda A. Wiens
- Steven T. DeKosky (ORCID: https://orcid.org/0000-0003-3743-2758)
- Idaly Vélez-Uribe (ORCID: https://orcid.org/0000-0001-8260-4630)
- Emily W. Paolillo (ORCID: https://orcid.org/0000-0003-4188-6998)
- Olivia M. Emanuel (ORCID: https://orcid.org/0000-0002-7667-2298)
- Rowan Saloner
- Tatjana Rundek
- Ranjan Duara
- Argentina Lario Lago
- Kaitlin B. Casaletto
- Julia D Webb
Institutions
- University of Miami (US)
- University of California, San Francisco (US)
- University of Florida Health (US)
- University of Florida (US)
- Mount Sinai Medical Center (US)
- Florida Atlantic University (US)
- Florida College (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/alz.70626
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Alzheimer's Association
- Larry L. Hillblom Foundation
- National Institutes of Health
- National Institute on Aging