Circulating Extracellular Vesicle miR-150–5p as a biomarker for optimizing clinical management of sepsis and septic shock: A discovery and validation Study
In conclusion, hsa-miR-150-5p levels exhibit a significant differential expression between septic shock and sepsis patients. This biomarker may help in early risk stratification and guide clinical decisions in post-surgical sepsis management. Moreover, our findings suggest its potential as a therapeutic target in sepsis, although its use as a therapeutic target requires further investigation.
Authors
- Hugo Gonzalo‐Benito (ORCID: https://orcid.org/0000-0001-8340-9909)
- Álvaro Tamayo-Velasco (ORCID: https://orcid.org/0000-0001-6202-5420)
- Salvador Resino (ORCID: https://orcid.org/0000-0001-8783-0450)
- Marta Martín-Fernández (ORCID: https://orcid.org/0000-0003-2714-8120)
- Amanda Fernández‐Rodríguez (ORCID: https://orcid.org/0000-0002-5110-2213)
- Esther Gómez Sánchez (ORCID: https://orcid.org/0000-0002-9457-1394)
- Belén Sánchez-Quirós
- Laura Sánchez-de Prada (ORCID: https://orcid.org/0000-0002-6929-8453)
- M.J. Lostes Bardaji
- Rodrigo Poves‐Álvarez (ORCID: https://orcid.org/0000-0002-2208-8969)
- Eduardo Tamayo (ORCID: https://orcid.org/0000-0001-8900-0944)
- María Heredia‐Rodríguez (ORCID: https://orcid.org/0000-0003-3691-0252)
- Pedro Martínez-Paz (ORCID: https://orcid.org/0000-0002-5772-8153)
- Óscar Gorgojo-Galindo
- María Ángeles Jiménez‐Sousa (ORCID: https://orcid.org/0000-0002-1945-6169)
- Rocío López-Herrero (ORCID: https://orcid.org/0000-0002-0295-7071)
- Alba Montero-Jodra (ORCID: https://orcid.org/0009-0007-6919-4105)
- Adrián García-Concejo
- R. Aller
- Paula Moreno-Portales
- Rosa Prieto-Utrera
- María Sherezade Tovar-Doncel (ORCID: https://orcid.org/0000-0002-8805-2328)
- Rosario Calaveras
Institutions
- Universidad de Valladolid (ES)
- Instituto de Salud Carlos III (ES)
- Centro de Investigación Biomédica en Red (ES)
- Instituto de Biomedicina y Genética Molecular de Valladolid (ES)
- Hospital Clínico Universitario de Valladolid (ES)
- Hospital Universitario Río Hortega (ES)
- Complejo Hospitalario Universitario de Toledo (ES)
Publication Details
- Journal
- Journal of Infection and Public Health
- Published
- 2025-09-05
- DOI
- https://doi.org/10.1016/j.jiph.2025.102966
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81