Extracellular Domain Shedding of TROP2 Activates EGFR Signaling to Drive Prostate Cancer Metastasis
Shed extracellular domain of TROP2 binds to and activates EGFR and stimulates the PI3K-AKT-mTOR signaling cascade to promote prostate cancer metastasis, providing potential biomarkers and therapeutic targets.
Authors
- Rosalie Nolley (ORCID: https://orcid.org/0009-0004-7269-5443)
- Sharon J. Pitteri (ORCID: https://orcid.org/0000-0002-3119-873X)
- Shiqin Liu (ORCID: https://orcid.org/0000-0001-5238-7137)
- James D. Brooks (ORCID: https://orcid.org/0000-0003-4521-7505)
- Alifiani B. Hartono (ORCID: https://orcid.org/0000-0003-1327-0811)
- Michael A. Liss (ORCID: https://orcid.org/0000-0001-6978-1026)
- Michelle Shen (ORCID: https://orcid.org/0009-0005-4105-5766)
- Chung S. Lee (ORCID: https://orcid.org/0009-0009-3351-6381)
- En‐Chi Hsu (ORCID: https://orcid.org/0000-0002-5671-6169)
- Tanya Ivanova Stoyanova (ORCID: https://orcid.org/0000-0003-0119-9747)
- Fernando Jose Garcia-Marques (ORCID: https://orcid.org/0000-0002-2105-2905)
- Hyeonji Hwang (ORCID: https://orcid.org/0009-0008-7185-9345)
- Francisco Solano (ORCID: https://orcid.org/0009-0005-8978-1169)
- Abel Bermudez (ORCID: https://orcid.org/0009-0002-3235-5538)
- Donna M. Peehl (ORCID: https://orcid.org/0009-0003-8592-7242)
- Merve Aslan (ORCID: https://orcid.org/0000-0002-0115-3426)
- Kewei Le (ORCID: https://orcid.org/0009-0004-3494-0823)
Institutions
- University of California, Los Angeles (US)
- National Health Research Institutes (TW)
- The University of Texas at San Antonio Health Science Center (US)
- Palo Alto University (US)
- University of California, San Francisco (US)
- University of New Orleans (US)
- Los Angeles Medical Center (US)
- University of California San Diego Medical Center (US)
- Stanford Medicine (US)
- Stanford University (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-09-05
- DOI
- https://doi.org/10.1158/0008-5472.can-24-4855
- Citations
- 1
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52