Extracellular Domain Shedding of TROP2 Activates EGFR Signaling to Drive Prostate Cancer Metastasis

Shed extracellular domain of TROP2 binds to and activates EGFR and stimulates the PI3K-AKT-mTOR signaling cascade to promote prostate cancer metastasis, providing potential biomarkers and therapeutic targets.

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Publication Details

Journal
Cancer Research
Published
2025-09-05
DOI
https://doi.org/10.1158/0008-5472.can-24-4855
Citations
1
Primary Topic
Prostate Cancer Treatment and Research
Type
article
Field-Weighted Citation Impact
1.52
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article

Extracellular Domain Shedding of TROP2 Activates EGFR Signaling to Drive Prostate Cancer Metastasis

Rosalie Nolley, Sharon J. Pitteri, Shiqin Liu, James D. Brooks et al.
1 citations
Cancer Research
Prostate Cancer Treatment and Research
1.52
article

Extracellular Domain Shedding of TROP2 Activates EGFR Signaling to Drive Prostate Cancer Metastasis

Rosalie Nolley, Sharon J. Pitteri, Shiqin Liu, James D. Brooks, Alifiani B. Hartono, Michael A. Liss, Michelle Shen, Chung S. Lee, En‐Chi Hsu, Tanya Ivanova Stoyanova, Fernando Jose Garcia-Marques, Hyeonji Hwang, Francisco Solano, Abel Bermudez, Donna M. Peehl, Merve Aslan, Kewei Le
article en
1 citations

Abstract

Shed extracellular domain of TROP2 binds to and activates EGFR and stimulates the PI3K-AKT-mTOR signaling cascade to promote prostate cancer metastasis, providing potential biomarkers and therapeutic targets.

Cancer ResearchVol. 85(23)
University of California, Los Angeles (US), National Health Research Institutes (TW), The University of Texas at San Antonio Health Science Center (US), Palo Alto University (US), University of California, San Francisco (US), University of New Orleans (US), Los Angeles Medical Center (US), University of California San Diego Medical Center (US), Stanford Medicine (US), Stanford University (US)
Openalex Percentile: Top 15%
Prostate Cancer Treatment and Research
1.52
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