Molecular MRI of Dysregulated Zinc Secretion Detects Pancreatic Ductal Adenocarcinoma and Response to <i>KRAS</i> <i>G12D</i> Inhibitor Treatment
Secretagogue-stimulated zinc secretion MRI is effective at detecting pancreatic cancer, monitoring treatment response, and determining cancer recurrence, offering a promising noninvasive imaging tool to improve patient management and outcomes.
Authors
- Stuti G. Shroff (ORCID: https://orcid.org/0000-0002-1674-2557)
- Jill Hallin (ORCID: https://orcid.org/0000-0002-8443-7116)
- Pamela Pantazopoulos (ORCID: https://orcid.org/0009-0003-1648-2796)
- Peter Caravan (ORCID: https://orcid.org/0000-0002-3179-6537)
- Mehrad Tavallai (ORCID: https://orcid.org/0009-0002-1540-7690)
- Motaz Qadan (ORCID: https://orcid.org/0000-0001-6951-8308)
- Jonah Weigand‐Whittier (ORCID: https://orcid.org/0000-0002-6647-9769)
- Ethan French (ORCID: https://orcid.org/0000-0002-0418-0489)
- Eric M. Gale (ORCID: https://orcid.org/0000-0003-4567-1126)
- Kenneth K. Tanabe (ORCID: https://orcid.org/0000-0003-1920-3417)
- Stephen C. Barrett (ORCID: https://orcid.org/0000-0002-8764-2027)
- Mozhdeh Sojoodi (ORCID: https://orcid.org/0000-0002-9946-5910)
- Nicholas J. Rotile (ORCID: https://orcid.org/0000-0001-6568-9927)
- Ibrahim Ragab Eissa (ORCID: https://orcid.org/0000-0001-9454-6327)
- Ian Ramsay (ORCID: https://orcid.org/0000-0003-1896-4337)
- Veronica Clavijo Jordan (ORCID: https://orcid.org/0000-0002-1468-164X)
- Manyu Jin (ORCID: https://orcid.org/0000-0001-7452-6898)
- Farzad Moloudi (ORCID: https://orcid.org/0000-0003-4480-2972)
- Nabeel El-Bardeesy (ORCID: https://orcid.org/0000-0003-3867-0416)
- Patricia Gonzalez-Pagan
Institutions
- Broad Institute (US)
- Harvard University (US)
- Gordon Center for Medical Imaging (US)
- Massachusetts General Hospital (US)
- Mirati Therapeutics (United States) (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
- Center for Cancer Research (US)
- Fate Therapeutics (United States) (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-09-05
- DOI
- https://doi.org/10.1158/0008-5472.can-24-3384
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00