ChREBP-Mediated Choline Deprivation and Chemokine Secretion Shape Tumor-Associated Macrophages to Promote Immune Evasion
ChREBP induces a choline-deprived tumor microenvironment and promotes chemokine secretion to facilitate immune evasion, suggesting targeting ChREBP as a therapeutic approach to improve the efficacy of immunotherapy.
Authors
- Wenyi Wei (ORCID: https://orcid.org/0000-0003-0512-3811)
- Baoxiang Chen (ORCID: https://orcid.org/0009-0001-9513-6618)
- Haisheng Yu (ORCID: https://orcid.org/0000-0002-3868-1732)
- Yongchang Wei (ORCID: https://orcid.org/0000-0001-7205-4663)
- Qun Qian (ORCID: https://orcid.org/0000-0001-8099-6925)
- Xiaoyu Xie (ORCID: https://orcid.org/0000-0002-8193-9487)
- Quanjiao Chen (ORCID: https://orcid.org/0000-0001-5993-5554)
- Congqing Jiang (ORCID: https://orcid.org/0000-0001-6324-5740)
- Xianghai Ren (ORCID: https://orcid.org/0000-0001-8092-6687)
- Jinfang Zhang (ORCID: https://orcid.org/0000-0001-8487-6007)
- Jianhong Zhao (ORCID: https://orcid.org/0009-0006-7408-7462)
- Siyuan Yin (ORCID: https://orcid.org/0009-0007-1429-4547)
- Jing Dai (ORCID: https://orcid.org/0000-0002-4433-4905)
- Lihong Fan (ORCID: https://orcid.org/0000-0002-7725-8128)
- Yanrong Deng (ORCID: https://orcid.org/0009-0005-6859-9800)
Institutions
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Wuhan University (CN)
- Wuhan Institute of Virology (CN)
- Zhongnan Hospital of Wuhan University (CN)
- The Pelvic Floor Institute (US)
- Hubei Cancer Hospital (CN)
- McGill University (CA)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-09-05
- DOI
- https://doi.org/10.1158/0008-5472.can-25-0235
- Citations
- 1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.80