Estimate of Coenzyme Q10 on the humeral immune response of infectious bursal disease with different programs recombinant and classical vaccine and liver function in Broilers

The aim of this study was to evaluate the impact of coenzyme Q10 dietary supplements on the humeral immune response (IgY) and certain liver functions including aspartate aminotransferase (AST) and alkaline phosphatase (ALP), in broiler Ross (308). vaccinated with different programs (recombinant HVT-IBD single dose at one day old, classical vaccines D78 at eight days old, and E228 at 16 days old). Two hundred and ten broilers were separated into seven categories, with 30 chicks each group. T1, feed Q10 (20 mg/kg diet) and vaccinated by (D78, E288); T2: feed Q10 (20 mg/kg diet) and vaccinated by (rHVT); T3: feed Q10 (40 mg/kg diet) and vaccinated by (D78, E288); T4; feed Q10 (40 mg/kg) and vaccinated by (rHVT): T5; vaccinated (D78, E288) only: T6; vaccinated (rHVT) only: T7; negative control. Immunoglobulin Y (IgY) titers were measured on day 15, revealing that groups T4 and T2 showed significantly higher titers (P≤0.05) compared to the other groups. Additionally, data from days 25 and 33 showed a consistent increase in IgY levels across the experimental period. Furthermore, serum antibody titers for viral diseases and the liver enzymes AST and ALP were significantly altered in Q10-treated groups compared to controls (P≤0.05). In conclusion, dietary supplementation with coenzyme Q10 at levels of 20 mg/kg and 40 mg/kg resulted in a significant enhancement in serum antibody titers against infectious bursal disease (IBD), while liver enzyme activity declined over the course of the experiment.