PAX3-FOXO1 Drives Targetable Cell State–Dependent Metabolic Vulnerabilities in Rhabdomyosarcoma
PAX3-FOXO1+ rhabdomyosarcoma cells and tumors exhibit increased sensitivity to DHFR inhibition via methotrexate, identifying a potential therapeutic vulnerability that can be exploited to treat this aggressive pediatric sarcoma.
Authors
- Lydia W.S. Finley (ORCID: https://orcid.org/0000-0003-4023-7574)
- Kristina Guillan (ORCID: https://orcid.org/0009-0007-9668-9859)
- Abigail Xie (ORCID: https://orcid.org/0000-0001-6771-1980)
- Armaan Siddiquee (ORCID: https://orcid.org/0009-0007-1464-3786)
- Benjamin T. Jackson (ORCID: https://orcid.org/0000-0003-1089-4362)
- Joshua D. Rabinowitz (ORCID: https://orcid.org/0000-0002-1247-4727)
- Sangita Chakraborty (ORCID: https://orcid.org/0009-0008-7674-8150)
- Andrew L. Kung (ORCID: https://orcid.org/0000-0002-9091-488X)
- Filemon S. Dela Cruz (ORCID: https://orcid.org/0000-0002-8356-5191)
- Angela M. Montero (ORCID: https://orcid.org/0009-0003-8846-2268)
- Julia S. Brunner (ORCID: https://orcid.org/0000-0002-3195-147X)
- Daoqi You (ORCID: https://orcid.org/0000-0003-4363-5893)
- Katrina I. Paras (ORCID: https://orcid.org/0000-0001-9743-5710)
- Jacob A. Boyer (ORCID: https://orcid.org/0000-0001-5651-2337)
- Lourdes Pajuelo Torres (ORCID: https://orcid.org/0000-0002-6578-6687)
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Duke University (US)
- Princeton University (US)
- Cornell University (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-09-05
- DOI
- https://doi.org/10.1158/0008-5472.can-25-0315
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00