An Olive Oil–Based High-Fat Diet Promotes Obesity-Driven Metastasis of Triple-Negative Breast Cancer
Comparison of obesity induced by different high-fat diets revealed that an olive oil-based diet promotes triple-negative breast cancer metastasis by activating FABP5/PKC/ALDH signaling, providing a target for the development of obesity-associated cancer therapeutics.
Authors
- Yiqin Xiong (ORCID: https://orcid.org/0000-0003-4138-5851)
- Melissa Curry (ORCID: https://orcid.org/0009-0001-3796-1046)
- Yi Huang (ORCID: https://orcid.org/0000-0002-9982-117X)
- Anthony M. Avellino (ORCID: https://orcid.org/0000-0001-9072-9660)
- Jerry Li (ORCID: https://orcid.org/0009-0004-9693-5560)
- Ingrid M. Lizarraga (ORCID: https://orcid.org/0000-0001-9376-1746)
- Sonia L. Sugg (ORCID: https://orcid.org/0000-0001-7530-8526)
- Zhaohua Wang (ORCID: https://orcid.org/0000-0002-0209-5811)
- Jianyu Yu (ORCID: https://orcid.org/0000-0002-1856-2189)
- Jiaqing Hao (ORCID: https://orcid.org/0000-0002-2834-7255)
- Shanshan Liu (ORCID: https://orcid.org/0000-0003-3376-881X)
- Michael Lee (ORCID: https://orcid.org/0009-0001-4658-5441)
- Bing Li (ORCID: https://orcid.org/0000-0001-5363-7070)
- Xiaochun Han (ORCID: https://orcid.org/0009-0006-8926-648X)
- Xingshan Jiang (ORCID: https://orcid.org/0009-0000-1590-6794)
- Jonathan Shilyansky (ORCID: https://orcid.org/0009-0006-2155-0011)
Institutions
- University of Iowa (US)
- Yale University (US)
- University of Iowa Holden Comprehensive Cancer Center
Publication Details
- Journal
- Cancer Research
- Published
- 2025-09-05
- DOI
- https://doi.org/10.1158/0008-5472.can-25-0822
- Citations
- 1
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.81