Enhancing Oncology-Specific Question Answering With Large Language Models Through Fine-Tuned Embeddings With Synthetic Data

Our findings highlight the effectiveness of pretrained contextual embeddings and sentence transformers in retrieving pertinent notes from oncology EHRs. The innovative use of LLM-synthesized query-passage pairs for data augmentation was proven to be effective. This fine-tuning approach holds significant promise in specialized fields like health care, where acquiring annotated data is challenging.

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Publication Details

Journal
JCO Clinical Cancer Informatics
Published
2025-09-01
DOI
https://doi.org/10.1200/cci-25-00011
Primary Topic
Topic Modeling
Type
article
Field-Weighted Citation Impact
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article

Enhancing Oncology-Specific Question Answering With Large Language Models Through Fine-Tuned Embeddings With Synthetic Data

Zahra Eftekhari, Chi Wah Wong, Kun‐Han Lu, Allen Mao et al.
JCO Clinical Cancer Informatics
Topic Modeling
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Enhancing Oncology-Specific Question Answering With Large Language Models Through Fine-Tuned Embeddings With Synthetic Data

Zahra Eftekhari, Chi Wah Wong, Kun‐Han Lu, Allen Mao, Sina Mehdinia, Kingson Man
article en

Abstract

Our findings highlight the effectiveness of pretrained contextual embeddings and sentence transformers in retrieving pertinent notes from oncology EHRs. The innovative use of LLM-synthesized query-passage pairs for data augmentation was proven to be effective. This fine-tuning approach holds significant promise in specialized fields like health care, where acquiring annotated data is challenging.

JCO Clinical Cancer InformaticsVol. 9(9)
City Of Hope National Medical Center (US), City of Hope (US)
Openalex Percentile: Top 88%
Topic Modeling
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