Renal amyloid protein deposition in a Shar Pei dog

Renal amyloidosis is a glomerular disease with a familial predisposition, particularly common in Shar Pei dogs, and is associated with clinical manifestations of chronic kidney disease (CKD). This case report describes a female Shar Pei diagnosed with renal amyloidosis, similar to her father and brother. A nine-year-old female Shar Pei presented with a history of vomiting, halitosis, hyporexia, polyuria, and polydipsia. Structural and functional renal abnormalities were observed, including azotemia, cortical hyperechogenicity, and a mild reduction in corticomedullary differentiation. Given the patient’s clinical condition, euthanasia was performed, and renal tissue samples were submitted for histopathological analysis. The presence of eosinophilic fibrillar material within the glomeruli and some tubules confirmed the diagnosis of renal amyloidosis.