Significance of the amino acid at position 2561 in the C4 domain of von Willebrand factor
This study indicates that the amino acid at 2561 is crucial for modulating VWF function by helping to mediate stem dynamics.
Authors
- Alain Chion
- Golzar Mobayen (ORCID: https://orcid.org/0009-0007-3847-5035)
- Thomas A J McKinnon
- Fan Gong (ORCID: https://orcid.org/0000-0003-4328-4018)
- Xiao Hui Zhang (ORCID: https://orcid.org/0000-0002-8778-595X)
- Stephen Rothery
- Yi Liu (ORCID: https://orcid.org/0000-0001-9748-0650)
Institutions
- Royal College of Surgeons in Ireland (IE)
- University of Massachusetts Amherst (US)
- Imperial College London (GB)
Publication Details
- Journal
- Journal of Thrombosis and Haemostasis
- Published
- 2025-09-05
- DOI
- https://doi.org/10.1016/j.jtha.2025.08.023
- Primary Topic
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Foundation for the National Institutes of Health
- British Heart Foundation