Novel Association Between SCN1A Mutation and Central Sleep Apnea: A Case of Basilar-Type Migraine

We report a 37-year-old woman with recurrent episodes of excessive daytime sleepiness, bizarre behavior, social delays, and confusion lasting 3–5 days. Between episodes, she experienced only mild migraine-like headaches. Genetic testing identified an SCN1A mutation, which may cause central sleep apnea, basilar-type migraine, and a channelopathy-related encephalopathic state in her. This is the first report linking an SCN1A mutation with central sleep apnea. We recommend future cohort studies to clearly examine the association between SCN1A mutation and central sleep apnea.