Oral Peptides And Proteins Delivery

Peptides and Proteins (PPs) have been used as therapeutic agents in treating many diseases. Therefore, the current review intends to focus on oral peptides and protein and different strategies for enhancing their oral absorption and permeation. Although the oral route is the preferred route of drug administration, it is challenging for PPs. Many biological barriers, such as pH, mucus, and enzymes, may restrict the absorption of PPs. Therefore, many approaches are used to overcome these difficulties, prove absorption, and enhance the bioavailability of PPs such as enzyme inhibitors, mucoadhesive, nanoparticles, active targeting, ,and many other techniques. Each approach is needed to obtain a good PP oral delivery; hence, multiple formulation techniques may be combined into one. In conclusion, this review display the important aspects of Peptides and Proteins, and the different approaches for enhancing their oral absorption and permeation.