St John’s Wort (Hypericum perforatum) Fresh Plant Tincture for Patients with Mild to Moderate Depression: A Prospective Observational Study

In an observational prospective patient cohort with mild to moderate depressive episodes corresponding to patients included in RCTs of hd-SJW, applying the same efficacy outcome and timeframe, C-SJW-ft showed comparable effects and good tolerability. Further clinical trials seem justified.