PIAS1 Shapes a Tumor-Suppressive Microenvironment by Suppressing Immune Evasion in Oral Squamous Cell Carcinoma
PIAS1 expression in stromal and immune cells is associated with tumor-suppressive reprogramming of the OSCC microenvironment. These findings position PIAS1 as a potential modulator of anti-tumor immunity and candidate target for therapeutic intervention.
Authors
- Shirin Bonni (ORCID: https://orcid.org/0000-0002-2649-8738)
- Martin Hyrcza
- Joseph C. Dort (ORCID: https://orcid.org/0000-0002-0858-187X)
- Pinaki Bose (ORCID: https://orcid.org/0000-0002-8338-2838)
- Steven C. Nakoneshny (ORCID: https://orcid.org/0000-0002-8920-0310)
- Parisa Ghahremanifard (ORCID: https://orcid.org/0000-0002-6583-5047)
- T. Wayne Matthews (ORCID: https://orcid.org/0000-0002-7596-6470)
- Shamir Chandarana (ORCID: https://orcid.org/0000-0001-6612-4717)
- Ayan Chanda (ORCID: https://orcid.org/0000-0002-2692-8558)
- Angela Chan (ORCID: https://orcid.org/0000-0002-7930-3949)
- Robert D. Hart (ORCID: https://orcid.org/0009-0003-7520-2096)
- J. An
Institutions
- Alberta Health Services (CA)
- University of Calgary (CA)
Publication Details
- Journal
- Cancers
- Published
- 2025-09-04
- DOI
- https://doi.org/10.3390/cancers17172905
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Breast Cancer Society of Canada