Co-existence of mcr-1 and blaCTX−M from porcine-derived Escherichia coli isolated in China and selection of mcr-1 under cephalosporins pressure
The observed high co-transfer efficiency, high stability rates, and low fitness costs of mcr-1 and bla<sub>CTX-M</sub> across distinct plasmid types and the mcr-1 selection driven by CEFs support the co-existence of mcr-1 and bla<sub>CTX-M</sub> in E. coli hosts. Our findings support the suggestion that there is an urgent need for coordinated antibiotic stewardship targeting both drug classes to curb multidrug-resistant (MDR) bacteria spread.
Authors
- Xue Ji (ORCID: https://orcid.org/0000-0002-9754-8739)
- Xuejun Guo (ORCID: https://orcid.org/0000-0002-6494-6183)
- Shiwen Sun
- Lin Zheng (ORCID: https://orcid.org/0000-0002-6865-4786)
- Gejin Lu
- Zixian Wang (ORCID: https://orcid.org/0000-0002-7950-787X)
- Bing Liang (ORCID: https://orcid.org/0000-0002-8607-6916)
- Lingwei Zhu
- Jingyi Guo (ORCID: https://orcid.org/0000-0001-9423-098X)
- Yang Sun (ORCID: https://orcid.org/0000-0003-1777-3803)
- Jing Jie (ORCID: https://orcid.org/0000-0001-8875-295X)
- Chuanfang Zhao (ORCID: https://orcid.org/0000-0001-7534-7410)
- B. Jiang (ORCID: https://orcid.org/0000-0002-7702-2959)
Institutions
- Jilin University (CN)
- Changchun Institute of Applied Chemistry (CN)
- Jilin Medical University (CN)
- Second Affiliated Hospital of Jilin University (CN)
- Jilin Academy of Traditional Chinese Medicine (CN)
- Institute of Special Animal and Plant Sciences (CN)
Publication Details
- Journal
- Journal of Global Antimicrobial Resistance
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1016/j.jgar.2025.08.018
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China