Micronutrient dynamics and deficiency risk across pregnancy and postpartum in a Slovak cohort

Our findings reveal significant differences in maternal micronutrient levels across pregnancy and postpartum. While some nutrients, including vitamin D and folate, remained relatively stable, others such as vitamin A, B12, iron and zinc were observed at lower levels, and vitamin E at higher levels during pregnancy. Vitamin E levels in the 3rd trimester frequently exceeded reference values for the general adult population, whereas zinc levels were significantly lower postpartum. We observed high prevalence of vitamin B12 and iron deficiencies, as indicated by transferrin saturation, particularly in the 3rd trimester. Vitamin D deficiency was prevalent throughout pregnancy and postpartum. Finally, our analysis demonstrated that dried blood spot (DBS) technology provides comparable results to venous blood analysis for measuring vitamin A, D and homocysteine levels.

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Publication Details

Journal
PLoS ONE
Published
2025-09-04
DOI
https://doi.org/10.1371/journal.pone.0331125
Primary Topic
Vitamin D Research Studies
Type
article
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article

Micronutrient dynamics and deficiency risk across pregnancy and postpartum in a Slovak cohort

Neha Basheer, Alexandra Krištúfková, Michal Fresser, Norbert Žilka et al.
PLoS ONE
Vitamin D Research Studies
article

Micronutrient dynamics and deficiency risk across pregnancy and postpartum in a Slovak cohort

Neha Basheer, Alexandra Krištúfková, Michal Fresser, Norbert Žilka, Katarina Koprdova, Matus Lieskovsky
article en

Abstract

Our findings reveal significant differences in maternal micronutrient levels across pregnancy and postpartum. While some nutrients, including vitamin D and folate, remained relatively stable, others such as vitamin A, B12, iron and zinc were observed at lower levels, and vitamin E at higher levels during pregnancy. Vitamin E levels in the 3rd trimester frequently exceeded reference values for the general adult population, whereas zinc levels were significantly lower postpartum. We observed high prevalence of vitamin B12 and iron deficiencies, as indicated by transferrin saturation, particularly in the 3rd trimester. Vitamin D deficiency was prevalent throughout pregnancy and postpartum. Finally, our analysis demonstrated that dried blood spot (DBS) technology provides comparable results to venous blood analysis for measuring vitamin A, D and homocysteine levels.

PLoS ONEVol. 20(9)
Slovak Academy of Sciences (SK), Slovak National Museum (SK), University Hospital Bratislava (SK), Institute of Neuroimmunology of the Slovak Academy of Sciences (SK), University of Ss. Cyril and Methodius in Trnava (SK), Comenius University Bratislava (SK)
Openalex Percentile: Top 66%
Vitamin D Research Studies
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