Membrane-Protective Effect of a Lipid Extract of the Marine Red Seaweed Ahnfeltia tobuchiensis (Kanno et Matsubara) Makienko under Experimental Carbon Tetrachloride Poisoning

Carbon tetrachloride (CCl4) disrupts the stable operation of biological membranes, causing disturbances in the lipid bilayer, as well as changes in the properties of membrane lipids. The protective effect of a lipid complex isolated from the marine red alga Ahnfeltia tobuchiensis and the reference drug “Essentiale” was investigated on the plasma membranes of mouse erythrocytes, obtained in the modeling of toxic hepatitis induced by CCl4. The lipid extract from A. tobuchiensis was not inferior in efficiency to the phospholipid preparation Essentiale in restoring the indices of both membrane lipids and blood plasma lipids, as well as in normalizing the parameters of antioxidant protection of the organism. The membrane-protective effect of algal extract is due to its multicomponent composition including glyco- and phospholipids with predominance of polyunsaturated fatty acids of the n-3 and n-6 families.