Arachidonic acid fuels inflammation by unlocking macrophage protein phosphatase 5 after myocardial infarction
The findings elucidate the conserved role of 5-lipoxygenase phosphorylation regulated LTB4 levels in MI and identify PP5 as a potential therapeutic target for the treatment of MI.
Authors
- Hongfeng Jiang (ORCID: https://orcid.org/0000-0002-9261-0433)
- Lei Shi (ORCID: https://orcid.org/0000-0003-1679-3618)
- Dao Wen Wang (ORCID: https://orcid.org/0000-0002-9774-3980)
- Zhong Xian
- Xilin Shen (ORCID: https://orcid.org/0000-0001-8746-5801)
- Chen Chen (ORCID: https://orcid.org/0000-0001-5080-9383)
- Ting Zhou (ORCID: https://orcid.org/0000-0002-0049-4595)
- Wenbin Cai (ORCID: https://orcid.org/0000-0002-8808-1129)
- Hongxi Yang (ORCID: https://orcid.org/0000-0002-9545-5715)
- Ding Ai (ORCID: https://orcid.org/0000-0001-5992-9904)
- Zhipeng Chen (ORCID: https://orcid.org/0000-0003-1381-1366)
- Qiang Liu (ORCID: https://orcid.org/0000-0002-6621-0591)
- Mingming Liu (ORCID: https://orcid.org/0000-0002-6750-5068)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-7508-4160)
- Jianping Li (ORCID: https://orcid.org/0000-0001-8920-3223)
- Fangfang Fan (ORCID: https://orcid.org/0000-0001-9815-6780)
- Suli Feng
- Haoyu Weng (ORCID: https://orcid.org/0009-0006-6318-5817)
- Jiawei Song (ORCID: https://orcid.org/0009-0006-7338-8917)
- Mulin Jun Li
Institutions
- Capital Medical University (CN)
- Peking University (CN)
- Tianjin Medical University General Hospital (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Beijing Anzhen Hospital (CN)
- Peking University First Hospital (CN)
- Second Hospital of Tianjin Medical University (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- European Heart Journal
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1093/eurheartj/ehaf493
- Citations
- 4
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 3.19