Educational outcomes associated with prenatal exposure to antiseizure medications: A systematic literature review and meta-Analysis
Prenatal exposure to first-generation ASMs, especially sodium valproate, was associated with increased educational support needs. Newer-generation ASMs appear to have a more favourable risk profile, though evidence remains limited, underscoring the need for further high-quality research to inform clinical practice.
Authors
- Scott McGill Nelson (ORCID: https://orcid.org/0000-0002-9099-3047)
- Michael Fleming (ORCID: https://orcid.org/0000-0002-2185-4502)
- Jill P. Pell (ORCID: https://orcid.org/0000-0002-8898-7035)
- Daniel Mackay (ORCID: https://orcid.org/0000-0001-5381-7098)
- Sarjit Singh
- Alexia Karain
- Lama A Shakhshir
Institutions
- Glasgow Royal Infirmary (GB)
- University of Glasgow (GB)
Publication Details
- Journal
- Seizure
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1016/j.seizure.2025.08.016
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health and Care Research Wales
- Scottish Government
- UK Research and Innovation
- Cancer Research UK
- National Institute for Health and Care Research
- British Heart Foundation
- Public Health Agency
- Chief Scientist Office, Scottish Government Health and Social Care Directorate
- Medical Research Council
- Engineering and Physical Sciences Research Council
- Economic and Social Research Council
- Health and Social Care Research and Development Division