Trichiasis as a clinical manifestation of subconjunctival epithelioid hemangioendothelioma: a rare case report
Epithelioid hemangioendothelioma(EHE) is a rare, low-grade malignant tumor of vascular endothelial origin, commonly found in the lungs, liver, bones, and soft tissue. However, orbital involvement is uncommon. This study presents a rare case of EHE located in the orbit and confined to the subconjunctival space which has not been previously documented. An elderly male patient presented with a six-month history of discomfort in his left eye, initially diagnosed with lower eyelid trichiasis and scheduled for surgical intervention. A detailed examination identified a purplish, spherical mass beneath the fornix conjunctiva of the left lower eyelid. Computed tomography (CT) imaging of the orbit revealed a well-defined soft tissue mass beneath the left globe, adjacent to the inferior rectus muscle, with no evidence of invasion into the orbital cavity. Ultrasound showed a hypoechoic mass with abundant internal vascularity. Following complete surgical excision, histopathological analysis confirmed the diagnosis of EHE. Postoperative follow-up revealed no signs of recurrence, with full resolution of the trichiasis. No eye movement disorders or visual abnormalities were observed. Despite its generally low malignancy, EHE carries a risk of recurrence and metastasis. Complete excision is crucial to minimize recurrence risk, and long-term follow-up is essential for optimal management.
Authors
- Zhanfeng Wang
- Sirui Zhou (ORCID: https://orcid.org/0000-0003-4963-0815)
- Ting Luo (ORCID: https://orcid.org/0000-0003-1762-148X)
- Juan Guo (ORCID: https://orcid.org/0000-0001-8065-815X)
- Yuanyuan Chen (ORCID: https://orcid.org/0000-0002-7953-1845)
- Yi Sun (ORCID: https://orcid.org/0000-0002-6154-5341)
- Meilin Hu (ORCID: https://orcid.org/0000-0002-7699-0843)
- Jinlin Wang (ORCID: https://orcid.org/0000-0003-0525-6649)
Institutions
- Third People's Hospital of Chengdu (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-09-04
- DOI
- https://doi.org/10.3389/fonc.2025.1638365
- Primary Topic
- Vascular Tumors and Angiosarcomas
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health Commission of Sichuan Province