Cholinergic dysfunction in occupational manganese exposure
Higher Mn exposure is associated with lower cholinergic activity in multiple brain regions. Cholinergic function also mediates a portion of the relationship between Mn exposure and cognitive control performance. Caudate and cortical cholinergic activity may be a biomarker of early Mn neurotoxicity and represent an important mechanism of cognitive dysfunction in parkinsonian syndromes.
Authors
- Lianne Sheppard (ORCID: https://orcid.org/0000-0003-1622-508X)
- Tamara Hershey (ORCID: https://orcid.org/0000-0001-7549-0698)
- Joel S. Perlmutter (ORCID: https://orcid.org/0000-0003-3263-8917)
- Brad A. Racette (ORCID: https://orcid.org/0000-0002-9582-8235)
- Stephen M. Moerlein (ORCID: https://orcid.org/0000-0002-8897-092X)
- Anil Kumar Soda (ORCID: https://orcid.org/0000-0001-6818-078X)
- John O’Donnell (ORCID: https://orcid.org/0000-0003-0486-778X)
- Susan R. Criswell (ORCID: https://orcid.org/0000-0001-8467-371X)
- Hubert Flores
- Susan Searles Nielsen (ORCID: https://orcid.org/0000-0001-7768-4736)
- Natalie Senini
- Thomas E. Hutson (ORCID: https://orcid.org/0000-0002-4529-4212)
- Michael Kasper
- Zhude Tu
Institutions
- Barrow Neurological Institute (US)
- University of Washington (US)
- Washington University in St. Louis (US)
Publication Details
- Journal
- NeuroToxicology
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1016/j.neuro.2025.103313
- Primary Topic
- Heavy Metal Exposure and Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 0.00