Spatial and functional characterization of IL1RL1+ mast cells reveals immune regulatory roles in renal cancer
Our findings highlight the immune-regulatory role of IL1RL1<sup>+</sup> mast cells in ccRCC. IL1RL1 may contribute to anti-tumor immunity through the modulation of antigen presentation and CD8<sup>+</sup> T cell activation, offering new insights into its potential as a prognostic biomarker and therapeutic target in renal cancer.
Authors
- Weifeng Song (ORCID: https://orcid.org/0000-0001-5716-1698)
- Guangye Han
- Shuaiqi Chen
- Kuo Ma
- Zeyu Li (ORCID: https://orcid.org/0000-0002-4413-7581)
- Minghao Yue
- Chunfeng Zhang (ORCID: https://orcid.org/0000-0002-1191-4487)
Institutions
- Tianjin First Center Hospital (CN)
- First Affiliated Hospital of Xinxiang Medical University (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Molecular and Cellular Probes
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1016/j.mcp.2025.102049
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00