Demineralized Dentin Matrix Promotes Bone Regeneration Through IDO1-Mediated Th17/Treg Cell Balance Modulation
This study demonstrates that DDM regulates the Th17/Treg cell balance by promoting Treg cell differentiation through IDO1 upregulation, with minimal impact on Th17 cells. This immunomodulatory mechanism is a key factor underlying DDM's significant role in bone repair.
Authors
- Ling Peng (ORCID: https://orcid.org/0000-0003-2465-9056)
- Rongkun Chen
- Shuyu Zhu (ORCID: https://orcid.org/0009-0000-4331-9300)
- Zhiya Wang (ORCID: https://orcid.org/0000-0002-7764-6040)
- Xiangbing Meng (ORCID: https://orcid.org/0000-0002-9612-6438)
- Zhigang Xie (ORCID: https://orcid.org/0000-0003-4543-6783)
- Shu Zhang (ORCID: https://orcid.org/0009-0008-6739-1356)
- Jing Zhou
Institutions
- Kunming Medical University (CN)
- Stomatology Hospital (CN)
- Yan'an Hospital Affiliated To Kunming Medical University (CN)
Publication Details
- Journal
- International Dental Journal
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1016/j.identj.2025.103853
- Primary Topic
- Bone and Dental Protein Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00