Managing life-threatening complications of dengue fever in two sickle cell disease patients: A case series

Patients with sickle cell disease (SCD) infected with dengue virus are at high risk of developing severe complications. However, the optimal management approach for this patient population remains unclear. We report two cases of dengue-associated multiorgan failure in adolescents with hemoglobin SC (HbSC) disease, both of whom recovered following structured symptomatic management. Drawing upon the pathophysiological insights from existing literature, we propose an algorithm to guide clinical management in such complex cases.