Ablation of Sympathetic Nerve-β3 Adrenergic Receptor-mediated Adipose Tissue Lipolysis Attenuates Alcohol-induced Liver Injury in Mice
Our data indicates that binge drinking leads to the development of fatty liver and liver damage by activating adipose tissue sympathetic nerve-Adrb3-mediated lipolysis in mice.
Authors
- Piumi B. Wickramasinghe
- Chen Liu (ORCID: https://orcid.org/0000-0002-5922-0951)
- Joel K. Elmquist (ORCID: https://orcid.org/0000-0001-6929-6370)
- Lin Jia (ORCID: https://orcid.org/0000-0002-7653-7395)
- Alexandre Caron (ORCID: https://orcid.org/0000-0001-6939-6136)
- Junyu Liu (ORCID: https://orcid.org/0000-0002-3803-4068)
- Sreeja Eadha
- Preethi Parupalli
- Sarvani Ganapavarapu
Institutions
- The University of Texas at Dallas (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-09-04
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101623
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Texas at Dallas
- National Institute on Alcohol Abuse and Alcoholism