Gastric biopsies with prominent eosinophils: Clinicopathologic features and response to therapy

The criteria for 'histologic eosinophilic gastritis' can miss cases with clinically significant eosinophilia and our study results argue against using this term for pathology diagnosis. The majority of patients with increased gastric mucosal eosinophils present with non-specific GI symptoms and endoscopic findings. While a significant proportion of patients improve symptomatically without treatment or with anti-acid therapy, a small proportion of patients develop steroid-dependent, relapsing idiopathic disease that warrants additional clinical follow-up.