Salidroside suppresses gastric cancer progression via miR-1343-3p-mediated repression of ACOT11 and disruption of fatty acid metabolism
We demonstrate that salidroside exerts anti-proliferative effects in gastric cancer by targeting the miR-1343-3p/ACOT11/FFA lipid metabolism signaling pathway, disrupting cancer cell energy production. These regulatory factors hold promise as novel therapeutic targets for gastric cancer.
Authors
- Zhendong Zhang
- Pingyi Wang
- Yuxin Du (ORCID: https://orcid.org/0000-0001-7429-3238)
- Mingyuan Cao (ORCID: https://orcid.org/0000-0001-8960-0165)
- Xianglin Hou (ORCID: https://orcid.org/0000-0002-7234-7279)
- Xiaoping Wang (ORCID: https://orcid.org/0000-0001-9856-4549)
Institutions
- Sun Yat-sen University (CN)
- Xizang Minzu University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-09-04
- DOI
- https://doi.org/10.3389/fonc.2025.1651857
- Citations
- 2
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China