Abnormal Ca2+ handling and reduced Ito contribute to citalopram-induced QT prolongation and cardiac arrhythmias
CIT treatment resulted in QT prolongation and higher susceptibility of ventricular arrhythmia. Regions with serious cardiac alternans were mainly responsible for initiation of CIT-related arrhythmias. Abnormal Ca<sup>2+</sup> handling and decreased I<sub>to</sub>-related gene expression likely underlie the ionic mechanism and may be a novel target for CIT-related arrhythmias.
Authors
- Tangting Chen (ORCID: https://orcid.org/0000-0003-1122-642X)
- Min Zhao (ORCID: https://orcid.org/0000-0002-4551-043X)
- Jiamin Xie
- Yangpeng Li
- Xiaoqiu Tan (ORCID: https://orcid.org/0000-0003-0062-6209)
- Hongping Shen (ORCID: https://orcid.org/0009-0006-5736-6427)
- Li Liu (ORCID: https://orcid.org/0000-0002-1543-1511)
- Jianhong Li (ORCID: https://orcid.org/0009-0005-0373-0740)
- Yuqing Zheng
- Xueru Liu (ORCID: https://orcid.org/0000-0003-3106-5977)
- Juan Xiao (ORCID: https://orcid.org/0000-0002-3696-7649)
- Ming Lei (ORCID: https://orcid.org/0000-0002-0928-341X)
Institutions
- Southwest Medical University (CN)
- University of Oxford (GB)
- Affiliated Hospital of Southwest Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-04
- DOI
- https://doi.org/10.3389/fphar.2025.1613438
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Department of Science and Technology of Sichuan Province
- Luzhou Science and Technology Bureau