Nfkbia-driven neuroinflammatory pathways mediate depression following spinal cord injury

Our results suggest that neuroinflammation plays a crucial role in the onset of depression after SCI. This is supported by the activation of the IκB/p65 signaling pathway and the dysregulation of inflammatory cytokines. These findings align with clinical observations of mood disorders in patients with SCI and reflect known patterns of inflammatory cytokine dysregulation. This study underscores the significance of anti-inflammatory treatments and comprehensive neuropsychiatric management strategies in the rehabilitation of SCI patients.