Adipocyte‐specific <scp>IGF1R</scp> knockout activates the β‐catenin/apelin axis to combat diet‐induced obesity in male mice
We unveil a β-catenin/apelin-driven endocrine axis that reprograms energy metabolism under obesogenic stress. Therapeutically, targeting adipose IGF1R or apelin signalling could combat obesity while avoiding systemic toxicity. Limitations include unresolved β-catenin/Apln transcriptional mechanisms, APJ function and tissue-specific AMPK effects. Our findings redefine IGF1R's metabolic role and propose novel strategies for obesity-related disorders.
Authors
- Ai Mi (ORCID: https://orcid.org/0000-0002-9488-5334)
- Liyuan Ran (ORCID: https://orcid.org/0000-0002-8241-7138)
- Rui Ma (ORCID: https://orcid.org/0000-0002-7439-8344)
- Haoan Wang (ORCID: https://orcid.org/0000-0002-9036-3635)
- Xiaoshuang Wang (ORCID: https://orcid.org/0000-0003-1894-9444)
- Yingjie Wu (ORCID: https://orcid.org/0000-0002-2694-1971)
Institutions
- Dalian Medical University (CN)
- Jinan Central Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2025-09-03
- DOI
- https://doi.org/10.1111/dom.70091
- Primary Topic
- Apelin-related biomedical research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Department of Science and Technology of Liaoning Province
- National Key Research and Development Program of China