Similarities and differences in the intestinal actions of metformin and imeglimin
In conclusion, although metformin and imeglimin exerted similar effects on gene expression in the colon at the whole-tissue level, they showed distinct cell type-specific actions, and they differed in their influence on gut microbiota and intestinal glucose dynamics.
Authors
- Kaori Hozumi
- Akihiko Kondo (ORCID: https://orcid.org/0000-0003-1527-5288)
- Hiroshi Mizuma (ORCID: https://orcid.org/0000-0001-8970-9486)
- Yasuyoshi Watanabe (ORCID: https://orcid.org/0000-0003-2623-5599)
- Wataru Ogawa (ORCID: https://orcid.org/0000-0002-0432-4366)
- Masakazu Shinohara (ORCID: https://orcid.org/0000-0001-8724-0071)
- Kenji Sugawara (ORCID: https://orcid.org/0000-0002-6549-7885)
- Daisuke Sasaki (ORCID: https://orcid.org/0000-0002-8260-0717)
Institutions
- RIKEN Center for Biosystems Dynamics Research (JP)
- Kobe University (JP)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2025-09-03
- DOI
- https://doi.org/10.1111/dom.70075
- Citations
- 1
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Suzuken Memorial Foundation
- Cell Science Research Foundation
- Japan Agency for Medical Research and Development
- Boehringer Ingelheim Japan
- Japan Diabetes Foundation
- Japan Society for the Promotion of Science