Novel RNA-methylase HNRNPC promotes gastric cancer tumorigenesis by triggering the lactate-induced ferroptosis resistance
Overall, these findings revealed the novel role of ferroptosis-related HNRNPC on GC lactate accumulation and lactate-induced tumorigenesis in GC tumor microenvironment. The data revealed the importance of HNRNPC for lactate metabolism in GC tumor microenvironment, as well as the synergistic effect of HNRNPC on lactate-induced ferroptosis resistance.
Authors
- Mengqian Cui
- Lei Shen (ORCID: https://orcid.org/0000-0003-4040-8716)
- Jian Yang (ORCID: https://orcid.org/0000-0002-2273-4510)
- Guoqiang Yang (ORCID: https://orcid.org/0000-0003-0726-2217)
Institutions
- Central Hospital of Zibo (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-04
- DOI
- https://doi.org/10.3389/fimmu.2025.1612935
- Citations
- 2
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61