Identifying biomarkers of hepatic fatty acid metabolism disorder in sevoflurane-induced brain developmental injury by bioinformatics analysis
These findings demonstrate that neonatal sevoflurane exposure profoundly affects hepatic fatty acid metabolism and immune cell infiltration, involving specific key genes (including Dhcr24), perturbed pathways, and regulatory networks. The identified biomarkers and potential therapeutic targets provide a crucial foundation for developing more specific countermeasures against sevoflurane-induced neurodevelopmental toxicity, potentially via targeting the liver-brain metabolic axis.
Authors
- Kui Hu
- Kui Wang (ORCID: https://orcid.org/0000-0001-9613-406X)
- Xinlin Chen (ORCID: https://orcid.org/0000-0001-5161-0210)
- Haodong Sun (ORCID: https://orcid.org/0000-0002-5847-3471)
- Yuying Lv (ORCID: https://orcid.org/0000-0003-4094-6063)
- Haozheng Yuan
- Pei Fan (ORCID: https://orcid.org/0000-0002-6512-5731)
- Pengbo Zhang (ORCID: https://orcid.org/0000-0002-4341-9587)
- Pengyu Jia (ORCID: https://orcid.org/0009-0008-9913-0054)
Institutions
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Frontiers in Molecular Neuroscience
- Published
- 2025-09-04
- DOI
- https://doi.org/10.3389/fnmol.2025.1369365
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China