MicroRNA-18a-5p regulates hepatic lipid accumulation in response to high-fat diet
These results identify miR-18a-5p as a key regulator of lipid homeostasis and ER stress in MASLD, suggesting its potential as a novel therapeutic target. Understanding such molecular mechanisms is crucial for developing effective strategies against this increasingly prevalent liver disease.
Authors
- Sara Falvo
- Arianna Cuomo
- Antonia Lanni (ORCID: https://orcid.org/0000-0001-5797-0348)
- Nicoletta Potenza (ORCID: https://orcid.org/0000-0002-9736-792X)
- Massimo Venditti (ORCID: https://orcid.org/0000-0002-7357-5353)
- Rosalba Senese (ORCID: https://orcid.org/0000-0003-1571-0980)
- Federica Cioffi (ORCID: https://orcid.org/0000-0002-1530-8556)
- Giuseppe Petito (ORCID: https://orcid.org/0009-0006-5470-0354)
- Nunzia Magnacca
- Angelo Fusco
- Maria Ventriglia
Institutions
- University of Sannio (IT)
- University of Campania "Luigi Vanvitelli" (IT)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-09-04
- DOI
- https://doi.org/10.3389/fphys.2025.1661428
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università degli Studi della Campania Luigi Vanvitelli