miR-378a-5p targeting BRAF regulates CD4+T cells differentiation to Th1 under rEg.P29 induction
In summary, our findings reveal that under the induction of r<i>E</i>g.P29, miR-378a-5p targeted to BRAF regulation and initiated the differentiation of CD4<sup>+</sup>T cells in mouse spleen to Th1 direction, and MAPK/ERK pathway may be involved in this process, identifying miR-378a-5p as apotential biomarker and immunomodulatory target in CE.
Authors
- Tingting Zhang (ORCID: https://orcid.org/0000-0002-1919-1471)
- Mu Hu (ORCID: https://orcid.org/0000-0002-5566-1231)
- Chuan Wang (ORCID: https://orcid.org/0000-0002-0728-5745)
- Mingxing Zhu
- Bingshuo Qian
Institutions
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
- Ningxia Center for Diseases Prevention and Control (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-04
- DOI
- https://doi.org/10.3389/fimmu.2025.1620225
- Citations
- 1
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Natural Science Foundation of Ningxia Province