The early bird in renal rescue: timing matters in acute kidney injury management—insights from target trial emulation
Early initiation appears beneficial in the severe cohort (stage 3), but not in the broader cohort (stage ≥1), where it could even be harmful. This highlights the need for personalized treatment based on the severity of acute kidney injury and further research to optimize the timing of renal replacement therapy.
Authors
- Lili Hu (ORCID: https://orcid.org/0000-0002-7470-0830)
- Jinhu Zhuang (ORCID: https://orcid.org/0000-0003-3139-6282)
- Xiang Yuan Zheng (ORCID: https://orcid.org/0000-0003-4899-1643)
- TQ Thach (ORCID: https://orcid.org/0000-0003-3404-3888)
- Xi Chen (ORCID: https://orcid.org/0000-0003-3855-2591)
- Mengyi Wang (ORCID: https://orcid.org/0000-0002-9348-6876)
- Xiaxia Yu (ORCID: https://orcid.org/0000-0003-4811-5125)
- Yong Liu (ORCID: https://orcid.org/0000-0001-8101-8322)
- Kin F. Cheung
- Miaowen She
Institutions
- Hubei University of Medicine (CN)
- Hong Kong Polytechnic University (HK)
- Shenzhen University (CN)
- Taihe Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-09-04
- DOI
- https://doi.org/10.3389/fmed.2025.1645046
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Guangdong Medical Research Foundation