Preparation and Evaluation of Amorphous Solid Dispersion of Etoricoxib, Employing A Fast Approach for Polymer Selection
The solubility increased from 99.08 to 296.8 μg/ml and the dissolution rose from 69.32% to 98.07%. These findings suggest that the kneading method and Poloxamer successfully produced amorphous solid dispersions of etoricoxib with significantly enhanced solubility and dissolution properties, potentially improving its bioavailability.
Authors
- Ashwini Madgulkar (ORCID: https://orcid.org/0000-0002-4693-6459)
- Minakshi B. Shinde
- Mangesh R. Bhalekar (ORCID: https://orcid.org/0000-0003-0000-5859)
- Jitendra W. Gajbe (ORCID: https://orcid.org/0000-0003-1346-9847)
- Bandenawaz M. Shaikh (ORCID: https://orcid.org/0009-0009-3593-7833)
Institutions
- Shri Ramswaroop Memorial University (IN)
- Spicer Adventist University (IN)
Publication Details
- Journal
- Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
- Published
- 2025-09-04
- DOI
- https://doi.org/10.2174/0118715230357451250812171047
- Primary Topic
- Drug Solubulity and Delivery Systems
- Type
- article
- Field-Weighted Citation Impact
- 0.00