Population structure and emergence of resistance to new and repurposed drugs in XDR-TB: insights from a 10-year genomic study in the Western Cape, South Africa review
Near-untreatable Atypical Beijing strains are prevalent in the WCP. Hence, hotspot areas for clustering in Cape Town Metropole, Cape Winelands and Garden Route HCDs should be prioritised for targeted intervention to prevent ongoing XDR-TB transmission.
Authors
- Marisa Klopper (ORCID: https://orcid.org/0000-0002-9318-8289)
- Robin M. Warren (ORCID: https://orcid.org/0000-0001-5741-7358)
- Christoffel J. Opperman (ORCID: https://orcid.org/0000-0002-6676-5431)
- Yonas Ghebrekristos (ORCID: https://orcid.org/0000-0003-2002-5240)
- Johannes Loubser (ORCID: https://orcid.org/0000-0002-2362-0187)
- Elizabeth M. Streicher (ORCID: https://orcid.org/0000-0003-3901-1981)
- Elizna Maasdorp (ORCID: https://orcid.org/0000-0002-3402-169X)
- Sarishna Singh (ORCID: https://orcid.org/0000-0002-1794-4126)
- Justice Trésor Ngom (ORCID: https://orcid.org/0000-0001-9437-1483)
Institutions
- National Health Laboratory Service (ZA)
- South African Medical Research Council (ZA)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-09-04
- DOI
- https://doi.org/10.3389/fcimb.2025.1638577
- Citations
- 1
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.40