Effect of H2S on endothelial barrier function impairment in anorectal vascular plexus caused by deoxycholic acid
GYY4137 can improve the distribution of TJPs by inhibiting the activation of the MLCK-P-MLC2 signaling pathway induced by DCA, thereby protecting the VEBF in AVP, which may be applied to hemorrhoids therapy in the future.
Authors
- Jing Zhu (ORCID: https://orcid.org/0000-0001-9748-8361)
- Shaorong Pan (ORCID: https://orcid.org/0000-0003-2298-9166)
- Yuanyuan Ma (ORCID: https://orcid.org/0000-0002-2116-3306)
- Zhidong Chen (ORCID: https://orcid.org/0000-0002-9383-9563)
- Pengyuan Wang (ORCID: https://orcid.org/0000-0003-3884-0227)
- Yalun Li (ORCID: https://orcid.org/0000-0002-6977-1626)
- Han Yan
Institutions
- Peking University (CN)
- Peking University First Hospital (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-09-04
- DOI
- https://doi.org/10.3389/fmed.2025.1537723
- Primary Topic
- Gastroesophageal reflux and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Peking University First Hospital
- Peking University
- Fundamental Research Funds for the Central Universities