FLT3L combined with GM-CSF induced dendritic cells drive broad tumor-specific CD8+ T cell responses and remodel the tumor microenvironment to enhance anti-tumor efficacy
In summary, FLT3L combined with GM-CSF induced DCs, through their unique subpopulation composition and functional state, can more effectively expand tumor-specific CD8<sup>+</sup> T cells and reshape the tumor microenvironment, thereby achieving superior immunotherapy outcomes. This study highlights the potential of FL/GM-DCs as a next-generation DC platform, paving the way for improved clinical translation of DC-based adoptive cancer immunotherapies.
Authors
- Jianfeng Tan (ORCID: https://orcid.org/0000-0002-2523-2188)
- Yu Sun (ORCID: https://orcid.org/0000-0001-5002-1414)
- Hong‐Shu Sui
- Ming Qu (ORCID: https://orcid.org/0009-0005-0146-9358)
- Zhanhao Mo (ORCID: https://orcid.org/0000-0002-3908-4120)
- Ningning Lv
- Jiajie Zhang (ORCID: https://orcid.org/0000-0002-3510-4040)
- Bin Zhang (ORCID: https://orcid.org/0000-0002-9264-8554)
- Pengfei Zheng (ORCID: https://orcid.org/0009-0008-3433-2878)
- Lin Liu (ORCID: https://orcid.org/0000-0001-9672-0042)
Institutions
- Union Hospital (HK)
- Optech (Canada) (CA)
- Union Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-04
- DOI
- https://doi.org/10.3389/fimmu.2025.1649891
- Citations
- 2
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 1.59