Exploring bioactive phytochemicals as ULK1 activators for enhancing cytoprotective autophagy in amyotrophic lateral sclerosis
Candidine and Delavinone emerge as promising phytochemical activators of ULK1 with potential therapeutic relevance for ALS. These findings warrant further experimental validation and preclinical studies to explore their efficacy in autophagy modulation and neuroprotection.
Authors
- Maha M. Bakhuraysah (ORCID: https://orcid.org/0000-0002-9727-650X)
- Taj Mohammad (ORCID: https://orcid.org/0000-0002-0399-4835)
- Nahed M. Hawsawi (ORCID: https://orcid.org/0000-0002-6127-6508)
- Anas Shamsi (ORCID: https://orcid.org/0000-0001-7055-7056)
- Farah Anjum (ORCID: https://orcid.org/0000-0002-8597-6015)
- Maram Jameel Hulbah (ORCID: https://orcid.org/0009-0009-0314-2526)
- Abdulaziz Alsharif (ORCID: https://orcid.org/0000-0003-1377-9247)
- Abdulraheem Ali Almalki (ORCID: https://orcid.org/0000-0002-6838-6814)
Institutions
- Taif University (SA)
- Ajman University (AE)
- King Salman Center for Disability Research (SA)
- Jamia Millia Islamia (IN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-04
- DOI
- https://doi.org/10.3389/fphar.2025.1661744
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ajman University
- King Salman Center for Disability Research